Tony Pulis has left Crystal Palace by mutual consent.
Pulis, 56, met with chairman Steve Parish earlier in the day amid reports of friction between the pair over areas of responsibility.
The former Stoke manager has been frustrated by the failure to land a number of his transfer targets during the summer.
Assistant manager Keith Millen will be in temporary charge for Saturday's trip to Arsenal.
Bookmakers' odds had tumbled as speculation over Welshman Pulis' job intensified.
The remainder of Pulis' coaching staff - including Gerry Francis and Dave Kemp - have been asked by Parish to stay on for the Arsenal game before leaving the club.
Pulis wanted to assume greater control of all football matters at Selhurst Park - especially transfers.
It has been the role of Parish and sporting director Iain Moody to deliver the players that Pulis earmarks.
Moody joined from Cardiff City in November where he had held a similar role before being dismissed by the owner Vincent Tan.
Palace signed Liverpool full-back Martin Kelly on Thursday, while striker Fraizer Campbell arrived from Cardiff for £900,000 and former Fulham centre-back Brede Hangeland joined on a free.
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