The rise of the likes of Red Bull came out of rule changes and them having Adrian Newey to exploit the rules best possible a la Colin Chapman in the 60s and 70s.
With the new set of rules another clued up designer may be able to beat the big teams. But the big money teams soon catch up as they of course have the money to chuck at it. Arsenal or Ajax for example can't go into a wind tunnel and develop their own Messi
Big teams will of course get preferential treatment same as in football, just look at Man U's usual fixture list to see that or the the fact this meeting has been arranged to discuss Hamilton after he caused a Ferrari a problem.